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Meg Ryan has posted a tribute to the departed filmmaker Rob Reiner, who was her director in the iconic rom-com When Harry Met Sally.

A Heartbreaking Event

Reiner was discovered deceased alongside his spouse, Michele Singer Reiner, at their home in Los Angeles this past weekend.

“We will miss this man so deeply…” Ryan wrote on Instagram, next to an image of them together. “Our gratitude, Rob and Michele, for your faith in true love, stories, and joy. We appreciate your faith in human goodness and your deep patriotism.”

Legal Proceedings Unfold

Reiner’s son Nick, 32, is accused of two counts of first-degree murder and appeared in court today. He’s being held without bail. Reports indicate that Reiner’s daughter Romy was the one who located her father.

“I have to believe that their story will not end with this impossible tragedy, that some good may come, some awareness raised,” Ryan added. “Perhaps they would desire a legacy of hope and humanity, leading us toward empathy and tranquility.”

Family Members Issue a Message

Reiner’s other children Jake and Romy shared a statement today. “Language fails to capture the daily agony we endure,” they said. “The horrific and devastating loss of our parents, Rob and Michele Reiner, is something that no one should ever experience. Beyond being our mom and dad, they were our dearest friends.”

Peers Pay Their Respects

Ryan’s co-star, Billy Crystal, similarly honored Reiner via comments shared yesterday together with remarks by Larry David, Martin Short and Albert Brooks.

“His comedic touch was beyond compare, his love of getting the music of the dialogue just right, and his sharpening of the edge of a drama was simply elegant,” it read. “He adored his actors. He elevated his writers. His greatest gift was freedom. If you had an idea, he listened, he brought you into the process. Everyone felt like part of a crew. His direction was a gift, but his legacy is broader.”

A Storied Career

When Harry Met Sally was a box office and critical triumph in 1989, earning over $93 million globally and earning Nora Ephron an Oscar nomination for best original screenplay.

Rob Reiner met Michele Singer Reiner while making When Harry Met Sally. The pair were connected through Barry Sonnenfeld, a friend and director.

Reiner’s extensive filmography featured classics such as Misery, Stand by Me and The Princess Bride. The director and his wife were together in marriage for 36 years.